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First Take: The new PNAS study is also observational, but with an important twist: It zeroes in on that third factor possibility by studying twins, 789 in California and 2,277 in Minnesota

The E Cigarette is a general category of products being discussed in this article, encompassing a variety of devices and e-liquids

Sold in a standard 20-cigarette box, these are available at Costco in multi-pack carton configurations

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It also refers to the smoke released from a burning cigarette, cigar, or pipe

The overall direction of effect was less consistent than for Appeal, but overall (four of seven studies) tended to favour standardised packaging