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The nicotine in tobacco is a drug and, like many drugs, it is addictive

Research Triangle Park, North Carolina Van Duuren BL, Goldschmidt BM (1976) J Natl Cancer Inst 56:12371242 Veglia F, Loft S, Matullo G et al (2008) Carcinogenesis 29:932936 Wang M, Cheng G, Balbo S et al (2009) Cancer Res 69:71707174 West KA, Brognard J, Clark AS et al (2003) J Clin Invest 111:8190 Witschi H (2000) Exp Lung Res 26:743755 Witschi H (2005) Exp Lung Res 31:318 Wynder EL, Graham EA, Croninger AB (1953) Cancer Res 13:855864 Yuan JM, Koh WP, Murphy SE et al (2009) Cancer Res 69:29902995 Zhang S, Villalta PW, Wang M et al (2006) Chem Res Toxicol 19:13861392 Zhao C, Kumar R, Hemminki K (2000) Biomarkers 3:327334 Zhao C, Tyndyk M, Eide I et al (1999) Mutat Res 424:117125 Acknowledgments Studies in the Hecht laboratory on cigarette smoking and cancer are supported by grants CA-81301 and CA-92025 from the National Cancer Institute and grant ES-11297 from the National Institute of Environmental Health Sciences

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