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Nicotine from a smoked cigarette will reach the brain in as little as 7 seconds after inhalation. The addictive effect of nicotine is linked to its capacity to trigger the release of dopamine a chemical in the brain that is associated with feelings of pleasure

however, organophosphates have longer-lasting effects on neurotransmitter levels in both humans and pests that make them more toxic than carbamate pesticides

Later, in 1811, Benjamin Brodies experiments on animals revealed that nicotine was toxic, meaning that the days of tobacco enemas were numbered

However, the use of nicotine should always be approached with caution due to its high addiction potential and associated health risks

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