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Certain retained components of various cell death pathways such as Fas (CD95)/Fas ligand (FasL, CD95L) signaling, caspase-3, caspase-8, or RIPK1/RIPK3 (receptor-interacting serine/threonine-protein kinase 3)/MLKL (mixed lineage kinase domain like pseudokinase) axis can be considered a heritage of the erythroid lineage cells

For example, if a component of a vape pen breaks during the assembly process, leading to overheating or an explosion, this might be a manufacturing defect

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In addition, hookah smoking was shown to be genotoxic, leading to DNA damage in lymphocytes, where the magnitude of its genotoxicity was higher than that induced by cigarette smoking [143, 144]