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People with these conditions experience depressive episodes marked by deep sadness and fatigue, which occur alongside contrasting episodes of mania or hypomania

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Thus, it is more important than ever for smokers to quit and for youth and young adults to stop using tobacco products, including e-cigs to protect their health, improve health outcomes and for the scientific community to develop new therapeutics targets associated with smoking and e-vaping

United States Department of Health and Human Services, FDA, Center for Tobacco Products, Modifications to Compliance Policy for Certain Deemed Tobacco Products Guidance for Industry DRAFT GUIDANCE

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