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ALCAR and KET also activated brainstem nuclei (locus coeruleus, diagonal band, and raphe nuclei) which send aminergic projections to cortical areas and spinal dorsal horns that are involved in pain and mood control (Freo et al., 2010

Multi-omics analysis identifies ATF4 as a key regulator of the mitochondrial stress response in mammals

302 A 2020 clinical trial randomized 40 participants with Parkinson's disease who had motor signs not fully controlled by medication or who were ineligible for deep-brain stimulation in a 2:1 ratio to receive FUS of subthalamic nuclei or a sham procedure as control