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Herein, we present a cross-sectional study on a cohort of 75 cEDS patients from 44 families with a confirmed molecular diagnosis focusing on the diagnostic criteria recognized in the current EDS nosology and on additional mucocutaneous, osteoarticular, musculoskeletal, cardiovascular, gastrointestinal, uro-gynecological, neuropsychiatric, atopic, and facial/ocular features, in order to investigate the multisystemic involvement and natural history of the disorder

His family history and ethos is the subject of An Irishmans a Laborer at Heart

The inner tray pushes through revealing cigarettes from the top

Cut out its outer edges

Given that the questionnaire contains 35 items, the initial sample size was determined to be at least 350 participants (10 times the number of items)

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