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both are achievable," the statement continued

This review article highlights the need for large, carefully designed, adequately controlled, long- term follow-up clinical trials to assess the true potential of combustion-free nicotine delivery technologies for sustained smoking cessation and reducing risk of harm from smoking, particularly among smokers with chronic obstructive pulmonary disease (COPD)

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However, as of 2021, e-cigarette use among Americans aged 5064 and 65 years is 2.9% (95% CI 2.3, 3.5) and 0.9% (95% CI 0.6, 1.2), respectively, compared to 10% for those aged 1834 years [23]