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Yet, considering the importance of mitochondrial dysfunction in COPD and the increasing evidence highlighting mtDNA gene expression and methylation as potential biomarkers in a variety of diseases related to mitochondrial dysfunction and ageing, future studies may explore the impact of age and smoking status of COPD patients to provide a deeper understanding on mtDNA methylation and gene expression

Helen (University of California San Francisco, USA), for critical review of the manuscript and Tyson Douglass (University of California San Francisco, USA) for editorial assistance

This can be especially challenging if one has close friends or family who smoke, as it can be difficult to explain to them that you are trying to quit

You will also be required to display a sign next to a machine stating that the law prohibits the selling of tobacco to persons under 21 years of age