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The most recent US Surgeon General report on smoking states that cigarettes kill 490,000 Americans every year

Co-authored by Raven Minyard, BA This article was co-authored by wikiHow staff writer, Raven Minyard, BA

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Nicotine activates, saturates and desensitizes dopamine pathway receptors, which is followed by growth or activation of millions of extra receptors, a process known as up-regulation

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