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These include liver and colorectal cancer, diabetes mellitus, ectopic pregnancy, erectile dysfunction, age-related macular degeneration, orofacial clefts in newborns (as a result of maternal smoking), rheumatoid arthritis, and health problems such as inflammation and impaired immune functioning

Research on these complex processes is important not only to understand the regulation of tobacco's response to fluctuating mineral supply and to excess metals, but might also have wide practical application in genetic modification of tobacco and other species

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In a meta-analysis, which examined 30 studies on early-onset colorectal cancer risk factors, being overweight or obese increased the likelihood of developing early-onset colorectal cancer by 1.2 and 1.5 times, respectively, compared to maintaining a healthy weight (165)Hua H, et al

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