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Abstract We conducted a two-sample Mendelian randomization study to determine the association of smoking initiation with seven psychiatric disorders

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The main factors contributing to this trend include peer pressure, curiosity, smoking cessation and the perception of reduced harm 11,12

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In the case of tauassociated diseases such as AD and FTD, impaired mitophagy and the associated accumulation of dysfunctional mitochondria are likely to comprise an important pathomechanism of neurodegeneration

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