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The FTND provides an ordinal measure of nicotine dependence, allowing researchers and clinicians to categorize individuals into different levels of nicotine dependence related to, ranging from low to high reliance

Despite early reports suggesting that smoking tobacco might have beneficial effects on cognition 7,8 and a reduced risk of dementia 9 , more recent evidence clearly suggests that active smoking has neurotoxic effects on the brain 10,11,12 and is associated with a doubling of dementia risk for older adults 13