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Other proinflammatory mediators, such as IL1B (interleukin-1b), TNF (tumor necrosis factor alpha), and PDGF (platelet-derived growth factor), work in a tight relationship with transcription factor KLF4 to promote a hostile environment in which vascular smooth muscle cells are lost and rupture of aneurysms occurs

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Meanwhile, Europe showcases a diverse landscape as several countries navigate varying levels of regulatory acceptance, contributing to innovation and market penetration