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Covariates Demographics (age, sex, education level, race/ethnicity), study site, date of enrollment in the parent study, years smoked, and cigarettes per day prior to the index hospital admission were obtained from the baseline survey completed at the parent study enrollment

Using gene set variation analysis (GSVA) of the core enriched genes from the PPP ( XYLB , RPE , and TALDO1 ) and arginine metabolism ( CPS1 , NAGS , ASS1 , CKM , AOC1 , and GATM ), together with the rate-limiting enzymes of the PPP ( G6PD and PRPS1 ), we confirmed that the PPP was upregulated (Figure 5, C and D) and that arginine metabolism was downregulated (Figure 5, E and F) in CR hi tumors compared with CR lo tumors in both the lung and liver tumors (Supplemental Tables 3 and 4)

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Individuals with tobacco addiction experience intense cravings, withdrawal symptoms upon cessation, and a persistent desire to continue tobacco use, even in the face of negative consequences

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