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Liquid chromatography coupled with mass spectrometry revealed shorter acyl chains in ceramides, and an increased proportion of sphingosine and 6-hydroxysphingosine ceramides (with C4 trans -double bond) over dihydrosphingosine and phytosphingosine ceramides in smokers, suggesting altered desaturase 1 activity

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Key findings to date include the following: IQOS vapour contains on average 90-95% lower levels of harmful and potentially harmful constituents excluding nicotine compared to cigarette smoke from a reference cigarette designed for scientific research purposes