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It avoids tar and combustion byproducts, but the nicotine can still narrow blood vessels and add oxidative stress, so heavy use may contribute to thinning in sensitive individuals

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Additionally, tobacco use remains the leading cause of preventable death in the U.S., claiming approximately 480,000 deaths each year

Metabolism and disposition kinetics of nicotine

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In 2000 , the prevalence of smoking among all income groups was 26.90 %, which gradually decreased to an estimated 17.30 % by 2025