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One study, for example, treated Sprague Dawley rats treated with gestational nicotine (3 mg/kg/day) and found that PNE offspring (P35/P36) had altered myelin expression of myelin-related transcription and trophic factors that produced alterations in myelin gene expression and oligodendrocyte functioning [165]

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[105] Coolidge had a penchant for animals and used her time in the White House to gather numerous pets, including several dogs and birds

By way of contrast, tobacco comprised the majority (around 7090%) of the product mass with dry snuff, hard pellet and soft pellet products