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Bibcode:2003Toxgy.187...25G

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Troutner, PhD, professor of chemistry

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Onion root tip cells exhibited reduced mitotic index, formation of micronuclei, lagging chromosomes, and c-mitosis.[] Chromosomal aberrations in PBL: Increased frequency of chromatid breaks, gap-type aberrations, and an increase in sister chromatid exchanges were observed in cultured PBL of male tobacco chewers,[] female masheri users,[] and mawa chewers with normal buccal mucosa, oral sumucous fibrosis, or oral cancer.[] A high proportion of tobacco processors with no tobacco habit and those with masheri habit exhibited a significantly elevated frequency of chromatid breaks and deletion fragments as compared to respective controls.[] SCE frequency was also elevated in the lymphocytes of habit-free tobacco processors.[] A significant increase in the frequency of chromosomal aberrations was observed in PBL from tobacco processors with or without smoking habits[] with the frequency of chromosomal aberrations increasing with the number of years of exposure

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