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Mechanism of smoking effects on pregnancy outcomes Nicotine and carbon monoxide (CO) are two main derivatives of tobacco that have a negative effect on pregnancy outcomes

PMID 17504235

But actually, there is evidence that suggests that some of these damaging particles can penetrate entryways even when theyre closed

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There are a variety of factors that are associated with tobacco use in pregnancy (socioeconomic status, nicotine addiction, unsupportive partner, stress, mental health illness etc.)