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Sp1 Suppresses miR-3178 to Promote the Metastasis Invasion Cascade via Upregulation of TRIOBP

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The key data points behind the Tobacco 21 law: A 2015 National Academy of Medicine report estimated that raising the purchase age to 21 could prevent approximately 223,000 premature deaths among people born between 2000 and 2019 The CDC reports that nicotine exposure during adolescence can harm brain development, which continues until approximately age 25, affecting attention, impulse control, learning, and mood Over 80% of adult smokers first tried tobacco before age 18, and nearly 95% before age 21 (Surgeon General's Report on Smoking Cessation, 2020) The 2023 National Youth Tobacco Survey found that 10% of high school students and 4.6% of middle school students reported current e-cigarette use down from a peak of 27.5% in 2019 The data shows the law is working

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