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PERP stimulates apoptosis by activating Caspase-8 to trigger the mitochondrion-Cytochrome c-caspase protease pathway or facilitating extracellular calcium loading into the endoplasmic reticulum (86)

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Discussion This study is an update on 2016 data from the Philippines based on the methodology used in the study by Cohen and colleagues (2021) which examined flavored cigarettes in low- to middle-income countries, specifically Bangladesh, Brazil, China, Indonesia, Philippines, Russia, Thailand, and Vietnam [35]

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