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Int J Hepatol

Statements Author contributions MC: Conceptualization, Writing original draft, Writing review & editing

Adeva-Andany MM, Prez-Felpete N, Fernndez-Fernndez C, Donapetry-Garca C, Pazos-Garca C

Diagnosis relies on B12 levels, methylmalonic acid, homocysteine, and intrinsic-factor antibodies interpreted by a clinician

Histones were precipitated from the supernatant by the addition of TCA at a final concentration of 20% TCA (v/v)

Interestingly, IR-deficient chondrocytes had increased IGF-1R levels and were more responsive to IGF-1 consistent with the notion that IGF-1/IGF-1R may compensate, at least in part, for loss of IR signaling