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Fisetin attenuates doxorubicin-induced cardiomyopathy and by inhibiting ferroptosis through SIRT1/Nrf2 signaling pathway activation

One of the hallmarks of cancer is the reprogramming of energy metabolism for the regulation of metabolism-related enzymes and transporters at transcriptional or post-transcriptional level (54)

Furthermore HLA-DR expression is reduced in the peripheral blood DCs of elderly subjects, which leads to diminished antigen presentation and contributes to the age-related decline in immune responsiveness [256]

25 The Superoxide dismutase requires a metallic catalyst for activation and provides defense against superoxide (O 2 ) particularly

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