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Salehi B, Berkay Ylmaz Y, Antika G, Boyunegmez Tumer T, Fawzi Mahomoodally M, Lobine D, Akram M, Riaz M, Capanoglu E, Sharopov F, Martins N (2019) Insights on the use of -lipoic acid for therapeutic purposes

This was observed with MC4-NN20453 which caused pigmentation-related AEs in the clinic as a result of its strong MC1R agonism from high sustained systemic exposures (26, 55, 57)

You may experience some mild swelling but this will typically resolve within a few days