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In addition, the benchmarking approach provides an alternative to the traditional validation of NAMS against apical effects in rodent studies but rather tries to evaluate the NAMs in the context of making protective safety decisions ( in vitro culture methodologies (van der Zalm et al., 2022)

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Also, it is known to have a significant role in producing the immune response and contributing to the pathogenesis of immense diseases such as rheumatoid arthritis

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Moreover, previous efforts to characterize archival pathological tissues have provided new insights into the tumour microenvironment using IMC in breast cancer 49,50 and melanoma 51 as well as in post-mortem COVID-19 specimens using IBEX 52