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10.1142/S0192415X18500362 Am J Chin Med

C4 cleavage is a key step of the classical/lectin pathways activation, generating two fragments: the larger C4b fragment that covalently binds to the target cell surface, and the smaller peptide C4a that is released (Fig

Psychotropics including fluoxetine, tricyclics, lithium, valproate, ketamine and others are explored in relation to their effect of PKC, finding that across all drugs examined, a downregulation with chronic-but not acute-use constitutes their putative effect in ameliorating symptoms

(The terminology is evolving internationally, with some guidelines now using metabolic dysfunction-associated steatotic liver disease [MASLD], though NAFLD remains the term in current UK guidance.) According to NICE guideline NG49 , NAFLD affects approximately 2030% of the UK population and is strongly associated with metabolic syndrome

doi: 10.1038/s41390-022-02136-2 38 WidjajaNAHamidahAPurnomoMTArdianahE