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These cultures were also capable of 3 H-DA uptake, but this activity, in contrast to the 3 H-DA uptake in midbrain cultures, was not blocked by the GBR12909 and instead was blocked by the NET-specific inhibitor desipramine indicating NET-mediated transporter activity in these cultures (Fig

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However, indirect mechanisms such as dehydration and electrolyte imbalances from gastrointestinal side effects may contribute to muscle cramping in some patients

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AOD-9604 also appears in pre-clinical literature exploring cartilage biology and connective tissue pathways, supporting non-clinical study setups in tissue engineering and regeneration-adjacent research contexts