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Sputum PGP is reduced by azithromycin treatment in patients with COPD and correlates with exacerbations

Through upregulating TP53 activity, GNA lowered the expression levels of GPX4 and SLC7A11, leading to dysregulation of cellular lipid peroxides, and eventually ferroptosis in transforming growth factor-1 (TGF-1)-induced EMT melanoma models (Wang et al., 2020)

However, the intrinsic pathway commences when the cell undergo stress such as DNA damage, which subsequently leads to mitochondrial cytochrome c release and interaction with activating factor-1 (APAF-1), to form an active apoptosome structure, which thereby activates procaspase 9