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This region of the brain regulates fear and is a key component in reward-seeking behavior related to addiction

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Tsuji-Naito et al 27 demonstrated that DHLHZn (sodium zinc dihydrolipoyl histidinate, compound of Zn2+/dyhydrolipoic acid derivative complex, which was developed for cosmetic/medical use) serves as a potentially effective skin-lightening agent, an effectiveness that is based on the compounds covalent scavenging of DOPAquinone, resulting in depigmentation

This absence of approval is echoed by regulatory agencies in countries like the UK, Canada, and Australia