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NPs can penetrate the CNS and potentially cause neuroinflammation and neurodegeneration

However, it also inhibits NOX-2, -3 and -4 and XO to some extent

Read-through agents could benefit CF patients affected by class I mutations, since this mutation causes the presence of a premature stop codon which precludes the synthesis of full-length CFTR protein

Int J Immunopathol Pharmacol 37:3946320231209839 Bennett T, Bray D, Neville MW (2014) Suvorexant, a dual orexin receptor antagonist for the management of insomnia

The study was limited by a single baseline exposure assessment, relatively short follow-up (maximum, 5 years), and high age at study entry (mean, 62 years at baseline)