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PLE is also effective when used alongside topical hydroquinone, sunscreen, or laser therapies

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The combined fractions were acidified with HC1 and lyophilized to offer the compound (206 mg, 82 %) as white solid, [(obs) MH + = 645.4] Exam le-IF: [0237] Step-1 : A mixture of 2-morpholinoacetic acid (975 mg, 6.73 mmol), 4-nitrophenol (850 mg, 6.12 mmol), DCC (1386 mg, 6.73 mmol) and DMAP (40 mg, 0.306 mmol) in DCM (50 mL) was stirred at room temperature overnight