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Additionally, caspase-8 regulates pyroptosis under specific conditions: nucleus-localised PD-L1 induces pyroptosis via caspase-8-mediated cleavage of GSDMC in the hypoxic tumour microenvironment [69]

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VEGF further stimulates the release of HGF from LSECs via VEGF/VEGFR2 signaling, reinforcing the regenerative process

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