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For example, the inhibition of histone deacetylases or demethylases interferes with the chromatin modifications that maintain DTP cells in a drug-tolerant state, such as the retention of closed or repressed chromatin at pro-apoptotic loci, thereby restoring susceptibility to drug-induced apoptosis (55)

Aparna, V., Dineshkumar, K., Mohanalakshmi, N., Velmurugan, D

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