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Uptake of the anticancer drug cisplatin mediated by the copper transporter Ctr1 in yeast and mammals

It is believed that more in-depth studies will explore and reveal the current limited molecular mechanism of ferroptosis, thus providing more enough scientific basis for the clinical application of targeting ferroptosis to the prevention and treatment of AS

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After the administration of MPTP, the mRNA expression of NFATc2 in brain tissues showed an elevation, which was later repressed by miR-214-3p to hinder the transcription process of NFATc2

By catalyzing Fenton reactions that convert superoxide and hydrogen peroxide into reactive toxic hydroxyl radicals, iron can induce ferroptosis and subsequent neuronal injury [99]