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Altered bacterial populations have been observed to initiate the synthesis of genotoxins like colibactins (produced by Escherichia coli ), CDTs (cytolethal distending toxins produced by Gram-negative bacteria), and endonucleases (produced by Neisseria gonorrhoeae )

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83 Although animal research suggests hops do not strongly trigger proliferation in endometrial and breast tissues, there have been reports of endometrial thickening and bleeding in postmenopausal women using hops, and its long-term safety in women with a history or high risk of breast cancer is uncertain