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Impact on WBCs: Checkpoint inhibitors typically do not significantly increase overall WBC counts, but they can increase the activity or presence of specific types of immune cells, like activated T cells and lymphocytes

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Final Action: After consideration of public comments, we are finalizing, effective January 1, 2026, our proposal to supplant the existing affirmation requirement with the proposed attestation statement at new 180.50(a)(3)(iii), with a modification to add the following phrase to the beginning of the attestation: To the best of its knowledge and belief,

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