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10 Compared with non-tumor cells, tumor cells usually maintain high levels of NADPH, not only to power redox defense but also to use for biosynthetic reactions to sustain their rapid growth

Aberrant expression or mutation of USP7 has been linked to the development and progression of various cancers, underscoring its potential as a therapeutic target

doi: 10.1016/j.neuron.2008.10.013 290 CunninghamCDunneALopez-RodriguezAB

It works by neutralizing free radicals, regenerating other antioxidants like vitamins C and E, and binding to toxins so the liver can safely eliminate them

Furthermore, the deletion of NRF2 resulted in decreased resistance to ferroptosis caused by artesunate due to GSH deficiency and heightened ROS levels both in vivo and in vitro [89]

b , c ) Smad3 gene expression levels in iSPN + at 3 M (Control vs Mutant, p = 0.2) and 8 M (Control vs Mutant, p = 0.004 **)