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In cultured hippocampal neurons, however, it seems that glutamate loading is associated with Cl efflux, and luminal Cl is critical for efficient vesicle acidification, indicating pivotal roles of luminal Cl on glutamate refilling in living synapses (Martineau et al., Regulation of Vesicular Glutamate Content by Cytoplasmic Cations Through Cation/H + Exchange Mechanisms on Svs Biochemical analysis of isolated SVs revealed that SVs exhibit an electro-neutral cation/H + exchange activity, which converts pH to , thereby facilitating glutamate transport into SVs (Goh et al., + exchange activity (Preobraschenski et al., Cytosolic Na + concentration is maintained at relatively low levels (~15 mM) by the activity of Na + /K + -ATPases on the plasma membrane

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E.et al (2010)

This pain can be caused by common changes caused by inflammation, including but not limited to tissue damage, swelling of the affected area and pressure on surrounding nerves, as well as the release of chemicals that sensitize nerve endings and alter the perception of pain

Resveratrol protects against arsenic trioxide-induced nephrotoxicity by facilitating arsenic metabolism and decreasing oxidative stress

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