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267,268 Many aspects of SAM enzymology, however, remain to be explored

Abstract Amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease or Charcot disease, is a fatal neurodegenerative disease that affects motor neurons (MNs) and leads to death within 25 years of diagnosis, without any effective therapy available

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7 In fact, xCT is considered to be the main transporter of cystine in cancer (Table 1) 25,26,27 and its expression is controlled by nuclear factor erythroid 2-related factor 2 (NRF2), a master regulator of the cellular redox state, 28 highlighting the importance of xCT in an oxidative stress-resistant cancer cell phenotype

A prodrug nanoplatform via esterification of STING agonist and IDO inhibitor for synergistic cancer immunotherapy