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In contrast, females do not exhibit this cytosolic inhibitory response and show impaired regulation of GR nuclear translocation, associated with disorganized localization of FKBP51, which becomes predominantly nuclear (Palumbo et al., 2020)

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This is evidenced by the fact that premenopausal women have a decreased incidence of hypertension and cardiovascular disease as compared to men of the same age and women who are menopausal

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