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These findings suggest that si-PGC-1 LNP is stable in circulation and can efficiently deliver to tumor sites through tail vein injection

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Therefore, targeting tumor methionine metabolism could be a promising strategy to antagonize T cell exhaustion in the tumor microenvironment

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Ct values from technical replicates were averaged after calculating a coefficient of variation (CV) for each qPCR reaction to assess any inconsistency across replicates

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