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Only one SAM binding site is observed in CBS filaments Each Bateman module, assembled from the tandem CBS-1 and CBS-2 motifs, contains, in principle, two ligand-binding sites (S1 and S2) related by dyad symmetry (Supplementary Fig

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Thus, this underscores the need for next-generation subunit vaccines that elicit durable humoral and cellular immune responses ( Subunit vaccines, despite their excellent safety profile, often require potent adjuvants to enhance immunogenicity and achieve a sustained protective response against intracellular pathogens ( Recently, the role of B cells as non-canonical APCs has been recognized as crucial in prolonging the immunity following the repeated immunization ( Collectively, the present work explored the potential of a dual-adjuvant approach to induce durable and functionally active antigen-specific humoral responses against two pivotal Plasmodium liver-stage antigens, Pf CSP and Pb SLTRiP ( Materials and methods BALB/c and C57BL/6 mice, aged 68 weeks, were procured from Zydus Research Centre, Ahmedabad, India

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J Mol Graph Model 112:108115

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