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This first-in-first-out approach ensures peptides get used while still well within their shelf life

Ilgenfritz, H

TPH1 null mice were more susceptible than wild type mice to acetaminophen-induced hepatotoxicity at the doses of 250500 mg/kg, as evidenced by marked increases in serum activities of ALT and AST (Figure 1A)

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

Mutations targeting the two activity controller residues (Asn240 and Leu244) as well as the gatekeeper residue (Phe260) were designed to impair monophenolase activity of jr PPO1