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For example, it suppresses NF-B pathway activation, decreasing the production of TNF- and IL-1, and in turn reducing HSC activation and ECM synthesis

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Interestingly, FOLFOX failed to activate hepatic NF-B or cause liver injury in PAI-1 KO mice

This ultimately leads to the activation of gene transcription for MMPs, which are essential for the progression of tumors

Gilbert Syndrome