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Mitochondrial calcium dysregulation is a key contributor to mitochondrial dysfunction in PD 90

4.2 The rhoA/ROCK signaling pathway The RhoA/ROCK signaling pathway is integral to both the initial stages of AS, particularly endothelial cell dysfunction, and the later stages involving the formation and rupture of atherosclerotic plaques (65)

doi: 10.1016/j.ijbiomac.2024.135552

Scan the HPLC and mass-spec results

Calcium ion imbalance is a key contributor to the onset and progression of arrhythmia ( 2+ redistribution due to oxidative stress, inhibits calpain-1 activation, maintains calcium homeostasis, and prevents apoptosis in ISO-induced myocardial hypertrophy, reducing arrhythmia risk (Mei et al., 2015)

Strategies to reduce these risks include prescribing the drug in the smallest appropriate quantity and advising the patient on careful storage of the drug during the course of treatment and proper disposal of unused drug