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Although to our knowledge, there is no direct evidence of crosstalk between the GDH pathway and the GABA shunt, we speculate that the GDH pathway may interfere with the decarboxylating step of the GABA shunt by controlling the available glutamate via the action of Gdh1, Gdh2 and Gdh3 proteins under specific conditions

doi: 10.1167/iovs.09-3633 276 GehlbachPPurpleRL

Standard / Gradual Approach Rather than a slow escalation, the reference approach is a modest fixed dose within a short cycle: many research protocols cite 20 to 50 mcg once daily , sometimes split near the muscle groups trained that session, run for 4 to 6 weeks before a break [2]

and Li, H

10.18632/aging.205768 219 ZhangX.TangB.LuoJ.YangY.WengQ.FangS.et al (2024b)

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