Peptide-related impurities and aggregates could alter immune recognition, particularly for injectable formulations
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Liver inflammation (hepatitis) is operationally defined as a constellation of changes that represent a severe and generalized liver reaction and would require multiple diagnostic terms to adequately characterize (Figure 70)
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Thermodynamic studies indicate that these stabilizing effects are more pronounced within the context of complex RNA structures, suggesting that enhanced stability arises from mechanisms beyond simple canonical hydrogen bonding, such as improved base stacking [109, 110]

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