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Vitamin B12, also known as cobalamin , is a water-soluble vitamin found primarily in animal products such as meat , fish , eggs , and dairy

Additionally, kidney dysfunction can also impact the gut microbiome by causing a reduction in the population of proteolytic bacteria, altering the ratio of aerobic and anaerobic bacteria, and compromising intestinal epithelial barrier integrity

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Therefore, the strategic targeting of MDSCs to convert GBM from a "cold" tumor, refractory to immune response, to a "hot" tumor that responds favorably to immunotherapy holds significant therapeutic promise (Fig