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Preliminary animal studies show that exercise in high-fat diet mice resulted in reduced hepatic 4-HNE levels and upregulation of anti-apoptotic protein expression (Merry and Ristow, 2016)

Both Setria and SOD have strong safety profiles in clinical studies

10.1016/j.molcel.2018.08.004 Mol Cell

The randomized design, the considerable sample size and the assessment of multiple CIPN outcomes provide methodological robustness to the study

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